Malcolm Maden

Associate Professor
Ph.D. University
of Birmingham,
UK, 1975
326 BAR
Box 118525
Gainesville, FL
32611-8525
Tele: 352-392-5856
Fax: 352-392-3704
malmaden@zoology.ufl.edu

Research Interests

I study the development and regeneration of various organ systems including the limb, the lung and the nervous system from the point of view of one important signaling molecule, retinoic acid. I am interested in the relationship between development and regeneration, whether regeneration can be induced in the adult organism by understanding the role of developmental signaling molecules and evolutionary aspects of retinoic acid signaling.

Students Currently Supervised

Teala Tyson

PhD student, "the role of retinoic acid in amphibian nervous system regeneration"

Representative Publications

On lung regeneration:

STINCHCOMBE, S.V. & MADEN, M. (2008). Retinoic acid induced alveolar regeneration: critical differences in strain sensitivity. Am. J. Respir. Cell Mol. Biol. 38, 185-91.

MADEN, M. (2006). Retinoids have differing efficacies at inducing alveolar regeneration in a dexamethasone treated mouse model. Am. J. Resp. Cell Mol Biol. 35, 260-267.

HIND, M. & MADEN, M. (2004). Retinoic acid induces alveolar regeneration in the adult mouse lung. Eur. Resp. J. 23, 20-27.

MADEN, M. & HIND, M. (2004). Retinoic acid in alveolar development, maintenance and regeneration. Phil. Trans. R. Soc. Lond. B 359, 799-808.

On nervous system regeneration and maintenance:

PO, S.L., YIP, P.K., BUNTING, S, WONG, L-F., MAZARAKIS, N.D., HALL, S.,MCMAHON, S., MADEN, M. & CORCORAN, J.P. (2006). Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth. Dev. Biol. 298, 167-175.

YIP,P.K., WONG, L-F., PATTINSON, D., BATTAGLIA, A., GRIST, J., BRADBURY, E.J., MADEN, M., MCMAHON, S.B. & MAZARAKIS, N.D. (2006). Lentiviral vector expressing retinoic acid receptor b2 promotes recovery of function after corticospinal injury in the adult rat spinal cord. Human Mol. Genet. 15, 1-12.

WONG, L-F, YIP, P.K., BATTAGLIA, A., GRIST, J., CORCORAN, J., MADEN, M., AZZOUZ, M., KINGSMAN, S.M., KINGSMAN, A.J., MAZARAKIS, N.D. & MCMAHON, S.B. (2005). Retinoic acid receptor b2 promotes functional regeneration of sensory axons into the adult rat spinal cord. Nature Neurosci. 9, 243-250.

CORCORAN, J.P.T. & MADEN, M. (2004). Disruption of the retinoid signalling pathway causes a deposition of amyloid b in the adult rat brain. Eur. J. Neurosci. 20, 896-902.

CORCORAN, J.C., SO, P.L., BARBER, R.D., VINCENT, K.J., MAZARAKIS, N.D., MITHROPHANOS, K.A., KINGSMAN, S.M. & MADEN, M. (2002). Retinoic acid receptor-b2 and neurite outgrowth in the adult mouse spinal cord in vitro. J. Cell Sci. 115, 3779-3786.

CORCORAN, J.C., SO, P.L. & MADEN, M. (2002). Absence of retinoids can induce motoneuron disease in the adult rat and a retinoid defect is present in motoneuron disease patients. J. Cell Sci. 115, 4735-4741.

On development:

WILSON, L.J., MYAT, A., SHARMA, A., MADEN, M. & WINGATE, R.J.T. (2007). Retinoic acid is a potential dorsalising agent in the late embryonic chick hindbrain. BMC Dev. Biol. 7, 138.

CHAMBERS, D., MADEN, M. & LUMSDEN, A. (2007). RALDH-independent generation of retinoic during vertebrate embryogenesis by CYP1B1. Development 134, 1369-1383.

MADEN, M., BLENTIC, A., REIJNTJES, S., SEGUIN, S., GALE, E. & GRAHAM, A. (2007). Retinoic acid is required for specification of the ventral eye field and for Rathke’s pouch in the avian embryo. Int. J. Dev. Biol. 51, 191-200.

REIJNTJES, S., RODAWAY, A. & MADEN, M. (2007). The retinoic acid metabolizing gene, CYP26B1, functions in zebrafish to pattern the cranial neural crest. Int. J. Dev. Biol. 51, 351-360.

REINJTJES, S., BLENTIC, A., GALE, E. & MADEN, M. (2005). The control of morphogen signalling: Regulation of the synthesis and catabolism of retinoic acid in the developing embryo. Dev. Biol. 285, 224-237.

REIJNTJES, S., GALE, E. & MADEN, M. (2004). Generating gradients of retinoic acid in the chick embryo: Cyp26C1 expression and a comparative analysis of the Cyp26 enzymes. Dev. Dynam. 230, 509-517.

WILSON, L., GALE, E., CHAMBERS, D. & MADEN, M. (2004). The role of retinoic acid in the dorsoventral patterning of the spinal cord. Dev. Biol. 269, 433-446.

REIJNTJES, S., GALE, E. & MADEN, M. (2004). Generating gradients of retinoic acid in the chick embryo: Cyp26C1 expression and a comparative analysis of the Cyp26 enzymes. Dev. Dynam. 230, 509-517.

REIJNTJES, S., GALE, E. & MADEN, M. (2003). Expression of the retinoic acid catabolising enzyme CYP26B1 in the chick embryo and its regulation by retinoic acid. Gene Expr. Patterns 3, 621-627.

DIEZ DEL CORRAL, R., OLIVERA-MARTINEZ, I., GORIELY, A., GALE, E., MADEN, M. & STOREY, K. (2003). Opposing FGF and retinoid pathways control ventral neural patterning, neuronal differentiation and segmentation during axis extension. Neuron 40, 1-20.

BLENTIC, A., GALE, E. & MADEN, M. (2003). Retinoic acid signalling in the avian embryo identified by sites of expression of synthesising and catabolising enzymes. Dev. Dynam. 227, 114-127.

Reviews:

MADEN, M. (2007). Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat. Rev. Neurosci. 8, 755-65.

MADEN, M. (2006). Retinoids and the spinal cord. J. Neurobiol. 66, 726-738.

MADEN M. (2006). Analysis of retinoid signaling in embryos. In Growth Factor Signaling in the Embryos. M.Whitman & A.K.Slater (eds) pp87-128. CRC Press, Boca Raton, Florida.

WILSON, L. & MADEN, M. (2005). The mechanisms of dorsoventral patterning in the vertebrate neural tube. Dev. Biol. 282, 1-13.

MADEN, M. (2004). Retinoids in Lung Development and Regeneration. Current Topics in Dev. Biol. 61, 154-189.

MADEN, M. & HIND, M. (2003). Retinoic acid, a regeneration-inducing molecule. Dev. Dynam. 226, 237-244.

MADEN, M. (2002). Retinoid signalling in the development of the central nervous system. Nature Neurosci. 3, 843-853.

MCCAFFERY, P.J., ADAMS, J., MADEN, M. & ROSA-MOLINAR, E. (2003). Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogen. Eur. J. Neurosci. 18, 457-472.